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SaeR is the response regulator of the SaeRS two‐component signal transduction system, which is involved in regulating bacterial autolysis and biofilm formation. SaeR comprises an N‐terminal receiver domain and a C‐terminal effector domain. The effector domain possesses DNA‐binding and transactivation functions. Here, the effector domain of SaeR from Staphylococcus epidermidis was purified and crystallized...
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