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In article number 1801942, Xiao‐Yu Hu, Dongmei Zhang, Juli Jiang, Leyong Wang, and co‐workers develop a closed–loop insulin delivery platform based on a supramolecular strategy. Insulin can be transported to the blood vessel through this multiple stimuli‐responsive system. Under hyperglycemic conditions, the in situ generated H2O2 and acidic microenvironment leads to the efficient release of insulin...
A closed‐loop “smart” insulin delivery system with the capability to mimic pancreatic cells will be highly desirable for diabetes treatment. This study reports a multiple stimuli‐responsive insulin delivery platform based on an explicit supramolecular strategy. Self‐assembled from a well‐designed amphiphilic host–guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded...
The stimuli‐responsive behavior of supramolecular nanocarriers is crucial for their potential applications as smart drug delivery systems. We hereby constructed a glucose‐responsive supramolecular drug delivery system based on the host–guest interaction between a water‐soluble pillar[5]arene (WP5) and a pyridylboronic acid derivative (G) for insulin delivery and controlled release under physiological...
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