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Extracellular Vesicles
In article number 2211664, Yuehua Liu, Lin Yu, Liming Yu, and co‐workers, design a hypoxic treatment strategy to increase extracellular vesicles (EVs) production and boost their therapeutic efficacy. An injectable bioactive hydrogel is developed to improve the in vivo stability and retention of EVs, thereby synergistically accelerating bone regeneration. This simple but effective...
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as an appealing alternative to cell therapy in regenerative medicine. Unlike bone marrow MSCs (BMSCs) cultured in vitro with normoxia, bone marrow in vivo is exposed to a hypoxic environment. To date, it remains unclear whether hypoxia preconditioning can improve the function of BMSC‐derived EVs and be more conducive...
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