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In this work, a Love wave biosensing platform is described for detecting cancer-related biomarker carcinoembryonic antigen (CEA). An ST 90°-X quartz Love wave device with a layer of SiO2 waveguide was combined with gold nanoparticles (Au NPs) to amplify the mass loading effect of the acoustic wave sensor to achieve a limit of detection of 37pg/mL. The strategy involves modifying the Au NPs with anti-CEA...
Surface acoustic wave (SAW) biosensors possess advantages of high efficiency, low cost and label free detection, and have potential applications in clinical diagnostics. However, it is a great challenge for SAW biosensors to detect small concentrations of biomarkers in clinical sample. Nanomaterials have been widely used in bioanalysis techniques to fabricate highly sensitive biosensors. In this paper,...
The performance for biomolecular detection is closely associated with the interfacial structure of a biosensor, which profoundly affects both thermodynamics and kinetics of the assembly, binding and signal transduction of biomolecules. Herein, it is reported on a one‐step and template‐free on‐electrode synthesis method for making shape‐controlled gold nanostructures on indium tin oxide substrates,...
Temperature has great influences on the surface acoustic wave (SAW) biosensors. Different substrates were tested and the methods for improving the temperature performance of the SAW biosensors were discussed here. The effects of temperature on the SAW sensors mainly result from the temperature coefficient of the SAW device and the oscillating circuit. To eliminate the impact of environment, a twin...
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