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This study was designed to investigate the extent to which an octacalcium phosphate/gelatin (OCP/Gel) composite can repair rat calvarial critical-sized defects (CSD). OCP crystals were grown with various concentrations of gelatin molecules and the OCP/Gel composites were characterized by chemical analysis, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron...
Cell function to form bone would be influenced by local environment, such as mechanical stress and tissue fluid constituents over intracellular signal transduction to macroscopic order. For example, osteoblasts and osteocytes respond to mechanical stimuli by changing their metabolism, proliferation, and differentiation. Our recent study showed that the elevated extracellular calcium stimulated secretion...
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