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The present study investigated the possibility of multiple 5-HT 1 autoreceptor subtypes in the rostral raphe nuclei. Slices (350 μm) of rat dorsal or median raphe nucleus (DRN/MRN) were taken from male Wistar rats and superfused with artificial cerebrospinal fluid at 32 o C. Fast cyclic voltammetry at carbon fibre microelectrodes was used to monitor serotonin (5-HT) release following...
This study reports the effect of chronic paroxetine (10<space>mg/kg p.o., 21 days) on 5-HT 1B and 5-HT 1D autoreceptors controlling stimulated 5-HT efflux in slices of rat dorsal raphe nucleus. Electrically evoked 5-HT (10 pulses, 200<space>Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. 5-HT efflux was inhibited by CP 93129 (10 nM-10<space>μM)...
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