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An enduring criticism of antidepressants, including serotonin-selective reuptake inhibitors (SSRIs), remains their slow onset of action. Although the SSRIs act acutely on serotonin (5-HT) uptake, their clinical effect only becomes apparent following 2-3 weeks of treatment, possibly due to down-regulation of 5-HT autoreceptors in the dorsal raphe nucleus (DRN) [Chaput et al, 1991]. This leads to...
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