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In order to improve outcome, new, often more toxic chemotherapy regimens are continuously investigated in early breast cancer patients. Because the expected survival improvement is small, the possible increase in the negative effects of the new treatments should be carefully evaluated. Negative effects are represented not only by acute and chronic toxicity, but also by the adverse psychological impact...
Purpose:To evaluate if chemotherapy (CT) dose-intensificationjeopardizes radiotherapy (RT) dose-intensity (DI). Patients and methods:From 1992 to 1997, 247 stage I–IIbreast cancer patients, treated with conserving surgery, were treated at theNational Cancer Institute of Genoa in a randomized study comparing the sameCEF regimen delivered every two weeks (CEF14) or three weeks (CEF21). RT wasapplied...
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