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The abnormality of the regulating factors in cell cycle is closely related to carcinogenesis. Cyclin D is a G1 cyclin which governs G1 progression. Previously, we have shown a high incidence of cyclin D overexpression in SCC and actinic keratosis. In this study, we have analyzed the expression of cyclin D and p53 in Bowen's disease (BD) by immunohistochemistry. 12 of 25 and 13 of 25 BD had an overexpression...
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