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Over the past decade, the BH3-only BID likes p53, has emerged as a central player in linking death signals through surface death receptors to the core apoptotic mitochondrial pathway and life signals through cell cycle arrest. Recent studies indicate that pro-apoptotic activation of BID may be negatively regulated by its phosphorylation in response to DNA damage. BID itself plays a role in cell cycle...
Hypoxia can cause not only acute kidney injury but also chronic kidney diseases. Hypoxia-inducible transcription factors activated by hypoxia play an important role in the cellular and tissular adaptation to low oxygen conditions. Hypoxia-inducible transcription factor-1 is composed of α and β subunits. Hypoxia-inducible transcription factor-1α (HIF-1α) is known as a key regulator in protective role...
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