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We evaluated the levels of p53, p21/waf1/cip1, hsp 27 and hsp 70 proteins in confluent cultures of human pancreatic tumor cell lines during the expression of inducible thermotolerance (IT). Two of these cell lines have wild type, whereas the other two have mutant, p53 status. Three cell lines expressed a significant amount of IT (p<0.05 and better, one-tailed Student's t-test); the fourth manifested...
Human glioma cells were studied to evaluate the effect long duration mild hyperthermia (LDMH), (up to 48 h) had on radiosensitization following heating and this was compared to LDMH given concurrently during low dose-rate irradiation. LDMH did not induce thermotolerance in glioma cells. Thermal radiosensitization was observed for acute irradiation following LDMH. The thermal enhancement ratios...
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