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Bacitracin is a metal-dependent dodecapeptide antipeptide produced by Bacillus species. Microcalorimetry was used to study the antimicrobial activity of bacitracin and bacitracin–metal ion complexation inhibited on Staphylococcus aureus at 37°C. The affinity of metal ions binding to bacitracin was investigated by isothermal titration calorimetry and was as follows: Cu(II) ≥ Ni(II) > Co(II) > Zn(II) ≥ Mn(II)...
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