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Background
Progressive spreading of α‐synuclein via gut‐brain axis has been hypothesized in the pathogenesis of Parkinson's disease (PD). However, the source of seeding‐capable α‐synuclein in the gastrointestinal tract (GIT) has not been fully investigated. Additionally, the mechanism by which the GIT microbiome contributes to PD pathogenesis remains to be characterized.
Objectives
We aimed to...
Aims
To extract vertex‐wise features of the hippocampus and amygdala in Parkinson's disease (PD) with mild cognitive impairment (MCI) and normal cognition (NC) and further evaluate their discriminatory efficacy.
Methods
High‐resolution 3D‐T1 data were collected from 68 PD‐MCI, 211 PD‐NC, and 100 matched healthy controls (HC). Surface geometric features were captured using surface conformal representation,...