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Excess hepatic free cholesterol contributes to the pathogenesis of non-alcoholic steatohepatitis, and statins reduce cholesterol synthesis. Aim of this study was to assess whether statin use is associated with histological liver damage related to steatohepatitis.The relationship between statin use, genetic risk factors, and liver damage was assessed in a multi-center cohort of 1201 European individuals,...
TNFα induces insulin resistance and promoter polymorphisms of TNFα gene affect the release of this cytokine, implicated in the pathogenesis of HCV-related diabetes and fatty liver. The aim was to define whether in patients with HCV chronic hepatitis TNFα genotype influences TNFα activity, insulin resistance, and the severity of the disease.186 patients, 65% with steatosis, 17% with diabetes. TNFα...
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