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The impact of filler–lubricant particle size ratio variation (3.4–41.6) on the attributes of an immediate‐release tablet was compared with the impacts of the manufacturing method used (direct compression or dry granulation) and drug loading (1%, 5%, and 25%), particle size (D[4,3]: 8–114 μm), and drug type (theophylline or ibuprofen). All batches were successfully manufactured, except for direct compression...
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