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Neural stem cells (NSCs) are used to treat various nervous system diseases because of their self‐renewal ability and multidirectional differentiation potential. However, an insufficient ability to track their migration in vivo and poor control over their survival and differentiation efficiency are two major critical challenges for clinical application. Here, it is shown that when magnetic nanobubbles...
Precise quantification of intracellular iron contents is important to biomedical applications of magnetic nanoparticles. Current approaches for iron quantification rely on specialized instruments while most only yield iron quantities averaged over plenty of cells. Here, a simple and robust approach, combining digital optical microscopy with the Beer–Lambert's law, that allows for imaging stainable...
In article number 2005474, Qi‐Huo Wei, Ning Gu, and co‐workers show that by combining the Beer‐Lambert's law with digital optical microscopy, iron contents in individual cells can be imaged and quantified with high accuracy, better than femtogram per pixel. This technique can be deployed easily in research and clinical labs for studying biomedical applications of magnetic nanoparticles and disease...
Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)‐induced cytoprotective autophagy required TFEB is shown. Ag NPs‐induced nucleus translocation of TFEB through a well‐established mechanism involving dephosphorylation of TFEB at serine‐142 and serine‐211 but independent of both the mTORC1 and ERK1/2 pathways. TFEB nucleus...
Temperature is a key parameter to regulate cell function, and biochemical reactions inside a cell in turn affect the intracellular temperature. It's vitally necessary to measure cellular temperature to provide sufficient information to fully understand life science, while the conventional methods are incompetent. Over the last decade, many ingenious thermometers have been developed with the help of...
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