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We describe an optical tissue phantom that enables the simulation of drug extravasation from microvessels. The phantom consists of a microdialysis tubing bundle, to simulate the permeable blood vessels, immersed in an aqueous suspension of titanium dioxide (TiO2) to simulate tissue scattering. The intent is to facilitate testing of optical pharmacokinetics (OP) methods for monitoring local drug delivery...
Tumors send chemical signals to the body to trigger angiogenesis to fuel their growth. These new vessels are hyperpermeable compared to normal, mature vessels. A new type of cancer treatment, anti-angiogenic therapy, inhibits the tumor's ability to recruit new blood vessels, limiting tumor growth. When effective, these drugs lower the permeability of the tumor vasculature because the production of...
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