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This study took advantage of the recent discovery that the EphA4 signaling has anti‐catabolic effects on osteoclasts/macrophages/synoviocytes but pro‐anabolic effects on articular chondrocytes and sought to develop an EphA4 signaling‐based therapeutic strategy for osteoarthritis (OA) using a mouse model of OA/posttraumatic OA (PTOA). The injured joint of C57BL/6J mice received biweekly intraarticular...
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