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Recently, our group developed ultrasound (US)-responsive and mannose-modified gene carriers (Man-PEG 2000 bubble lipoplexes), and successfully obtained a high level of gene expression in mannose receptor-expressing cells following gene transfection using Man-PEG 2000 bubble lipoplexes and US exposure. We also reported that large amounts of plasmid DNA (pDNA) were transferred into the...
The development of gene transfection methods enhancing the level of gene expression under simple and low-toxic condition is required for gene therapy in clinical. Our group has developed the ultrasound (US)-mediated gene transfection method using Man-PEG 2000 bubble lipoplexes, which are US-responsive and mannose-modified gene carriers, and succeeded in obtaining the enhanced gene expression...
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