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Aberrant microRNA (miRNA) expression is associated with human tumors, including breast cancer (BC), and has diagnostic and therapeutic potential. BC tissue is characterized by distinctive miRNA signatures associated with cancer development or progression.We explored miRNA profiles from BC tissues by unsupervised hierarchical clustering. Functional analysis was based on miRNA-mRNA data integration...
Estrogen receptor (ER) status can predict the efficacy of endocrine therapy. However, the predictive significance of the progesterone receptor (PgR) is controversial in an adjuvant setting. Records of 758 ER+ breast cancer patients who received adjuvant tamoxifen (TAM) for 3–5 years were reviewed to evaluate the predictive value of PgR for TAM treatment in ER+/PgR+ and ER+/PgR− groups. By a median...
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