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Placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) converts glucocorticoids to 11-keto-products and is believed to play an important role in protecting fetuses from higher maternal glucocorticoid levels. Recent reports have speculated that prenatal glucocorticoid exposure leads to fetal growth retardation and adult offspring hypertension and hyperglycemia. To investigate the effects of placental...
To investigate the effects of thyroid hormone and testosterone on 11β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1), we measured changes in hepatic 11β-dehydrogenase activity and its mRNA levels in pubertal methimazole (MMI)-induced hypothyroid male rats following treatment with thyroxine ([T 4 ] 50 μg/kg/d) or testosterone (250 μg/d) for 14 days. Hypothyroidism in male rats markedly reduced...
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