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While earlier studies of Apaf-1 holo-apoptosome architecture revealed the spectacular heptameric wheel-like structure formed by Apaf-1, the central CARD disk responsible for caspase-9 recruitment remained incompletely resolved. In a recent issue of Structure, Su et al. (2017) describe a crystal structure of the complex between Apaf-1 CARD and caspase-9 CARD. Together with two recent cryo-EM structures,...
RIG-I protects host cells against various RNA viruses by sensing viral RNAs in the cytoplasm. Crystal structures of RIG-I C-terminal domain bound to 5′-triphosphate dsRNA unveils how RIG-I recognizes the 5′-triphosphate moiety, a hallmark of viral RNAs (Lu et al., 2010).
The first crystal structures of small interfering RNA (siRNA)-protein complexes revealed an elegant caliper-like principle of length selection of siRNAs.
Background: Malic enzymes catalyze the oxidative decarboxylation of malate to pyruvate and CO 2 with the concomitant reduction of NAD(P) + to NAD(P)H. They are widely distributed in nature and have important biological functions. Human mitochondrial NAD(P) + -dependent malic enzyme (mNAD-ME) may have a crucial role in the metabolism of glutamine for energy production in rapidly...
Background: Glycoprotein hormones influence the development and function of the ovary, testis and thyroid by binding to specific high-affinity receptors. The extracellular domains of these receptors are members of the leucine-rich repeat (LRR) protein superfamily and are responsible for the high-affinity binding. The crystal structure of a glycoprotein hormone, namely human choriogonadotropin (hCG),...
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