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This paper provides an up-to-date review from the intersecting point of both clinical and engineering frameworks. The text interwoves available measures, models and control algorithms for general anesthesia. The three main parts of general anesthesia: neuromuscular blockade (NMB), hypnosis and analgesia are critically observed and perused from a global objective perspective. The outcome of this review...
This work focuses on the problematic of modeling the drug diffusion process that occurs in the human body when an anesthetic drug is taken up. This is performed here using emerging tools from fractional calculus, i.e. by using fractional-order impedance models (FOIMs). A novel interpretation is given to the classical pharmacokinetic and pharmacodynamic models for drug uptake in the body. The major...
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