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Background
Neutrophil migration into the airways is a key process in neutrophilic asthma. Developmental endothelial locus‐1 (DEL‐1), an extracellular matrix protein, is a neutrophil adhesion inhibitor that attenuates neutrophilic inflammation.
Methods
Levels of DEL‐1 were measured in exhaled breath condensate (EBC) and serum in asthma patients by ELISA. DEL‐1 modulation of neutrophil adhesion and...
Background
Allergen source‐derived proteases are a critical factor in the formation and development of asthma. The cysteine protease activity of house dust mite (HDM) disrupts the epithelial barrier function. The expression of cystatin SN (CST1) is elevated in asthma epithelium. CST1 inhibits the cysteine protease activity. We aimed to elucidate the role of epithelium‐derived CST1 in the development...