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The effect of lacosamide (LCS), a functionalized molecule with anti-convulsant properties, on ion channels was investigated, with the aid of patch clamp technology and simulation modeling. In NSC-34 neuronal cells, LCS was found to block voltage-gated Na + current (I Na ) in a frequency- and concentration-dependent manner. With the two-step voltage protocol, a minimal change in the...
AimsThe electrical properties of Na+‐activated K+ current (IK(Na)) and its contribution to spike firing has not been characterized in motor neurons.
MethodsWe evaluated how activation of voltage‐gated K+ current (IK) at the cellular level could be coupled to Na+ influx through voltage‐gated Na+ current (INa) in two motor neuron‐like cells (NG108‐15 and NSC‐34 cells).
ResultsIncreasing stimulation...
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