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Background Excessive circular fatty acid, particlarly saturated fatty acid, can result in insulin resistance in skeletal muscle, but other adverse effects of fatty acid accumulation in myocytes remain unclear. Methods Differentiated C2C12 myotubes were used. The effects of palmitate on cell viability, glucose uptake, gene expression and myotube loss were evaluated by MTT assay, 2NBDG uptake, qRT-PCR,...
Controllability of system is basic conception for analyzing and designing system with modern control theory. Bond graph contains system structure properties and can determine state variables. A simple method of determining controllability with bond graph is introduced in the paper. Only by assigning causality form for all storages elements of system in bond graph, which comply with firstly assigning...
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