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Round cell sarcomas harboring CIC‐DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to partial morphologic and immunohistochemical overlap with Ewing sarcoma (ES), CIC‐DUX4‐positive tumors have generally been classified as ES‐like and managed similarly; however, a systematic comparison at the molecular and immunohistochemical levels...
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