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The transcription factor NF-κB regulates genes involved in innate and adaptive immune response, inflammation, apoptosis, and oncogenesis. Proinflammatory cytokines induce the activation of NF-κB in both transient and persistent phases. We investigated the mechanism for this biphasic NF-κB activation. Our results show that MEKK3 is essential in the regulation of rapid activation of NF-κB, whereas MEKK2...
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