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Ly‐GDI, Rho GTPase dissociation inhibitor beta, was found to be expressed parallel to the GM3 level in mouse B16 cells whose GM3 contents were modified by B4galt6 sense, B4galt6 antisense cDNA, or St3galt5 siRNA transfection. Ly‐GDI expression was increased on GM3 addition to these cells and decreased with D‐PDMP treatment, a glucosylceramide synthesis inhibitor. Suppression of GM3 or Ly‐GDI by RNAi...
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