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KRAS promoter can form G-quadruplex structure and regulate gene transcription. The drugs which can bind with G-quadruplex of KRAS promoter may be potential remedy for treatment of cancers associated with KRAS mutation. The interaction mechanism between the G-quadruplex of KRAS promoter and three isoquinoline alkaloids (jatrorrhizine, berberine and sanguinarine) has been investigated by UV-visible,...
3,4′,7,8-Tetrahydroxyflavone (3,4′,7,8-tetraHF) is a kind of plant flavonol, and possesses anti-inflammatory, anti-nociceptive and anti-platelet effects. For understanding its pharmacology, the binding mechanism of 3,4′,7,8-tetraHF to a model protein, human serum albumin (HSA), was probed by fluorescence and UV absorption and mass spectrometric approaches. The binding affinities of the drug with the...
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