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Assembly and deposition of amyloid β-protein (Aβ) in the brain is a fundamental process of Alzheimer’s disease (AD). We previously hypothesized that GM1 ganglioside-bound Aβ (GAβ) is an endogenous seed for Aβ assembly in brain. Recently, we have succeeded in generation of a monoclonal antibody specific to GAβ. Notably, this antibody, 4396C, per se substantially inhibits Aβ assembly in vitro. Here...
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