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A novel method is presented for immobilizing rare single cells on MEMS scale sensor sites. The presented method does not require immobilization site to be chemically functionalized. Immobilizing single cells precisely on MEMS sensor sites is a requirement for many single cell analysis methods—reliability of cell analysis directly depends on the reliability of immobilization. The presented method uses...
This paper illustrates the extension of Rayleigh wave based surface acoustic wave (SAW) device sensors previously developed by the authors to integration with microfluidics. The SAW device is first modeled with a microchannel and then analyzed using finite element method. Precise fabrication, alignment and bonding of polydimethylsiloxane (PDMS) microchannels on diced Y-Z lithium niobate substrates...
This paper presents a Lab-on-a-Chip (LoC) type MEMS scale non-invasive biosensor for detecting and differentiating tumor cells at single cell level based on their electrical properties. Presented device requires no cell labelling, cell stressing, cell immobilization or device functionalization. Device is composed of a microfluidic channel etched in silicon with semi-parallel micro-electrodes fabricated...
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