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Picroside III (Pic), an iridoid glycoside derived from Picrorhiza scrophulariiflora, exhibits therapeutic potential in mending damage to the intestinal mucosa. This study aimed to explore Pic′s regulatory impact on intestinal inflammation and the gut microbiota in mice with dextran sulfate sodium (DSS)‐induced colitis. The findings revealed that pretreatment with Pic mitigated the DSS‐induced escalation...
Cover Feature. Picrorhiza scrophulariiflora, a renowned bitter Chinese medicine, is known for its gastrointestinal thickening properties. Its active component, Picroside III (Pic), has demonstrated potential in ameliorating colitis. However, the precise mechanism of its action remains unclear. This study elucidates that Pic's favorable impact on colitis in mice is attributed to the inhibition of intestinal...