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Immunotherapy is a promising cancer therapeutic strategy. However, the “cold” tumor immune microenvironment (TIME), characterized by insufficient immune cell infiltration and immunosuppressive status, limits the efficacy of immunotherapy. Tumor vascular abnormalities due to defective pericyte coverage are gradually recognized as a profound determinant in “cold” TIME establishment by hindering immune...
Tumor Immunotherapy
Tumor vascular abnormalities is a profound determinant in the “cold” tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8‐RGD effectively induced tumor vascular normalization, by reprogramming the “cold” TIME to a “hot” tumor immune microenvironment and facilitated robust antitumor immunity. More in article number 2308638, Yongquan Qu, Jie...
The design and fabrication of NO‐evolving core‐shell nanoparticles (denoted as NC@Fe), comprised of BNN6‐laden COF@Fe3O4 nanoparticles, are reported. This innovation extends to the modification of 3D printed polyetheretherketone scaffolds with NC@Fe, establishing a pioneering approach to multi‐modal bone therapy tailored to address complications such as device‐associated infections and osteomyelitis...
Mechanically sensitive tissues (e.g., skeletal muscles) greatly need mechanical stimuli during the development and maturation. The extracellular matrix (ECM) mediates these signals through nonlinear viscoelasticity of collagen networks that are predominant components of the ECM. However, the interactions between cells and ECM form a feedback loop, and it has not yet been possible to determine the...
Diabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chronic inflammation, and increased susceptibility to infection. To tackle these challenges and provide a comprehensive therapeutic approach for diabetic wounds, the first coaxial electrospun nanocomposite membrane is developed...
Generating sufficient power from waste heat is one of the most important things for thermoelectric (TE) techniques in numerous practical applications. The output power density of an organic thermoelectric generator (OTEG) is proportional to the power factors (PFs) and the electrical conductivities of organic materials. However, it is still challenging to have high PFs over 1 mW m−1 K−2 in free‐standing...
Tailoring the interface between organic semiconductor (OSC) and ferromagnetic (FM) electrodes, that is, the spinterface, offers a promising way to manipulate and optimize the magnetoresistance (MR) ratio of the organic spin valve (OSV) devices. However, the non‐destructive in situ regulation method of spinterface is seldom reported, limiting its theoretical research and further application in organic...
A superior composite material consisting of MXene and ruthenium dioxide‐modified carbon cloth is synthesized by pulsed laser deposition and electrostatic self‐assembly, which is further utilized to construct a class of novel electrochemical (EC) sensors for kaempferol (KA) detection. The carbon‐cloth‐based electrodes modified by ruthenium dioxide and then MXene are characterized by X‐ray diffraction,...
Developing stable catalysts with higher selectivity and activity within a wide potential range is critical for efficiently converting CO2 to ethanol. Here, the carbon‐encapsulated CuNi nanoparticles anchored on nitrogen‐doped nanoporous graphene (CuNi@C/N‐npG) composite are designedly prepared and display the excellent CO2 reduction performance with the higher ethanol Faradaic effiency (FEethanol ≥...