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Key points
ATP‐sensitive K+ (KATP) channels mediate hypoxia‐induced cerebral vasodilatation and hyperperfusion in animals.
We tested whether KATP channels blockade affects the increase in human cerebral blood flow (CBF) and the maintenance of oxygen delivery (CDO2) during hypoxia.
Hypoxia‐induced increases in the anterior circulation and total cerebral perfusion were attenuated under KATP channels...
Key points
Hypoxaemia evokes a repertoire of homeostatic adjustments that maintain oxygen supply to organs and tissues including the brain and skeletal muscles.
Because hypertensive patients have impaired endothelial‐dependent vasodilatation and an increased sympathetic response to arterial oxygen desaturation, we investigated whether hypertension impairs isocapnic hypoxia‐induced cerebral and skeletal...
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