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Eine neue Klasse von Peptiden, deren Fähigkeit zur Störung zellulärer Membranen an eine enzymvermittelte Verschiebung des Faltungspotentials des Peptids in eine membranaktive Konformation gekoppelt ist, wird von J. Shi und J. Schneider in ihrer Zuschrift auf S. 13844 vorgestellt. Das Faltungspotential ist zellspezifisch und hängt von der Menge an alkalischer Phosphatase auf der Zelloberfläche ab....
Selectively targeting the membrane‐perturbing potential of peptides towards a distinct cellular phenotype allows one to target distinct populations of cells. We report the de novo design of a new class of peptide whose ability to perturb cellular membranes is coupled to an enzyme‐mediated shift in the folding potential of the peptide into its bioactive conformation. Cells rich in negatively charged...
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