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Although motion correction in medical imaging is well established and has attracted much interest and research funding, a gap still exists in that there is a lack of reliable, low-cost hardware to enable such techniques to be widely adopted in healthcare. For PET, motion during scanning causes image blur which degrades image quality and quantifiability. In most marker based motion tracking systems...
Measuring the spatially variant point spread function (PSF) on a PET scanner involves using a point source to sample the field of view (FOV) at multiple locations. However, since most clinically used isotopes have short half-lives, usually other non-clinically used long-lived isotopes are employed in practice. As such, due to the difference in positron range, non-optimal PSF models that do not correspond...
Brain dedicated scanners such as the High Resolution Research Tomograph (HRRT) can achieve spatial resolutions of 2–3 mm FWHM due to their small scintillators crystal size and a double crystal layer phoswich detector which permits some level of depth of interaction (DOI) to minimise parallax errors. Resolution can further be improved by resolution models (RM) within image reconstruction which may...
Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil,...
The current study aimed to derive accurate estimates of regional cerebral blood flow (rCBF) from noisy dynamic [15O]H2O PET images acquired on the High Resolution Research Tomograph (HRRT), whilst retaining the high spatial resolution of this scanner (2-3 mm) in parametric images. We compared the PET autoradiographic and the generalised linear least squares (GLLS) methods to the non-linear least squares...
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