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To investigate how specific amino acid residues affect human cannabinoid CB 1 receptor binding and activation, CHO cell lines stably expressing wild type and the phenylalanine 200 to alanine mutant of human cannabinoid CB 1 receptor (F200A) were examined. AM2233 functions as an agonist at the wild type receptor (EC 50 =0.93 nM), but behaves as an inverse agonist at F200A (EC...
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