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Here we demonstrate proof-of-concept for controlling cardiac fibroblast collagen secretion on a microfabricated poly(glycerol sebacate) scaffold by endocardial endothelial cells.
Poly(glycerol sebacate) (PGS) has become one of the most promising new tissue engineering scaffold materials-of-construction. We hypothesized that the lipase inhibitor Orlistat might be suitable for inhibiting lipase-mediated PGS degradation. Here we investigated whether Orlistat can: (1) be physically transported into PGS using 70% (v/v) ethanol in water as a carrier, (2) be stably entrapped within...
Mechanical and morphological anisotropy play key roles in the function of native cardiac tissues. In the current study, finite element simulations, morphological and mechanical analysis were used to investigate interactions between the geometry of accordion-like honeycomb poly(glycerol sebacate) scaffolds and cardiomyocytes seeded via a collagen solution gelled within the pores. Specifically, the...
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