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This study presents an integrated microfluidic system combining two techniques, including an optically-induced dielectrophoresis (ODEP) module for manipulation of drug particles and an UV-direct-writing module capable of patterning of hydrogel, for applications of digital drug cocktails. This system was able to provide an automatic and customized production of drug cocktails. Experimental results...
Direct drug delivery into inner ear can be achieved by three approaches: (1) diffusion of drug through round window; (2) injection of drug through round window; (3) cochleostomy or canalostomy. The latter two approaches are invasive and have the risk of hearing loss and vertigo. Drug diffusion through round window is only the noninvasive approach. However, how to enhance drug diffusion and how to...
In combination with drug loaded microbubbles (MBs), increased local concentrations can be achieved by the ultrasound (US) targeted drug release and transiently increased capillary permeability at the site of MBs destruction. To prove the mechanism of US mediated release of drug loaded MBs, this study designs a new model with a method combining the high frequency US image and in vivo bioluminescence...
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