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Regulation of gene expression has been shown to involve not only binding of transcription factor in target gene promoters but also characterization of histone around which DNA is wrapped around. Some histone modification, for example di-methylated histone H3 at lysine 4 (H3K4me2), has been shown to be associated with gene activation. However, no clear pattern has been shown to predict human promoters...
The segmentation of tissue regions in high-resolution microscopy is a challenging problem due to both the size and appearance of digitized pathology sections. The two point correlation function (TPCF) has proved to be an effective feature to address the textural appearance of tissues. However the calculation of the TPCF functions is computationally burdensome and often intractable in the gigapixel...
The segmentation of tissues in whole-slide histology images is a necessary step for the morphological analyses of tissues and cellular structures. Previous works have demonstrated the potential of two-point correlation functions (TPCF) as features for tissue segmentation, however the feature space is not yet well understood and computational methods are lacking. This paper illustrates several fundamental...
In this paper, we present a study on the relationships between Chronic Lymphocytic Leukemia (CLL) related clinical attributes using network visualization and analysis techniques. This work is the first step of our long-term project to identify novel biomarkers for CLL, working in coordination with the NCI-funded CLL Research Consortium (cll.ucsd.edu). By computing Spearman correlation coefficients...
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