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Background
The thoracic radiotherapy (TRT) target volume for limited‐stage small‐cell lung cancer (SCLC) has been controversial for decades. In this report, the final results of a prospective randomized trial on the TRT target volume before and after induction chemotherapy are presented.
Methods
After 2 cycles of etoposide and cisplatin, patients arm were randomized to receive TRT to the postchemotherapy...
BACKGROUND
Chemotherapy, target therapy, and immunotherapy are increasingly being used in the systematic treatment of nasopharyngeal carcinoma (NPC), during which the occurrence of hepatitis B virus (HBV) reactivation might increase. However, data regarding HBV screening and reactivation and the clinical management of NPC patients with HBV infections are lacking. This study was aimed at clarifying...
BACKGROUND
Tumor response to neoadjuvant chemotherapy using the regimen of cisplatin and 5‐fluorouracil could define high‐risk patients with locoregionally advanced nasopharyngeal carcinoma (NPC). However, the regimen of docetaxel, cisplatin, and 5‐fluorouracil (TPF) appears to be more effective than the regimen of cisplatin and 5‐fluorouracil. Therefore, one needs to redefine the high‐risk subpopulation...
BACKGROUNDThe optimal model of total dose and fraction size for patients with locally recurrent nasopharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT) remains unclear. The authors designed a randomized phase 2 clinical trial to investigate the efficacy of 2 different models, with the objective of determining an optimal model.
METHODSBetween January 2003 and December 2007, a...
BACKGROUNDThe objective of this study was to evaluate the long‐term survival and late toxicities of concurrent‐adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China.
METHODSPatients with stage III to IVB NPC were assigned randomly to receive radiotherapy (RT) alone (the RT group) or RT plus concurrent adjuvant chemotherapy (the CRT...
BACKGROUND:Controversies exist with regard to thoracic radiotherapy volumes for limited‐stage small cell lung cancer (SCLC). This study compared locoregional progression and overall survival between limited‐stage SCLC patients who received thoracic radiotherapy to different target volumes after induction chemotherapy.
METHODS:Chemotherapy consisted of 6 cycles of etoposide and cisplatin. After 2...
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