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Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), which is characterized by the reciprocal t (15;17) (q24; q21) translocation, resulting in PML–RARA gene fusion. Therapy‐related AML (t‐AML) is a serious complication after cytotoxic and/or radiation therapy in many malignant diseases. In this report, MLL/KMT2A‐MON2, with balanced chromosomal translocation t (11;12)...
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML‐RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18‐RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/...
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