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AlGaN/GaN high electron mobility transistors (HEMTs) were immobilized with various receptors, including antibodies, duplex DNA, and HIV reverse transcriptase (RT) enzymes to detect ligands, including peptides, SARS proteins, and HIV drugs, respectively. Signals generated by the sensors were fitted into binding-site models and analyzed. The dissociation constants of the ligand-receptor pairs and the...
In this study, we used antibody-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) for detecting a short peptide, and revealing the number of binding sites of the antibody for the peptide and the dissociation constants of the antibody-peptide complex. In our case, two binding sites were found on the ferritin heavy chain (FHC) antibody and the dissociation constants of the antibody-peptide...
In this article, we used AlGaN/GaN high electron mobility transistors (HEMTs) to construct the first label-free semiconductor-sensor-based binding assay to our knowledge. Our results suggested that the nucleotide-c terminal domain of SARS coronavirus (SARS-CoV) nucleocapsid protein interaction is a two-step binding event with two dissociation constants (Kd1 = 0.052 nM, and Kd2 = 51.24nM) extracted...
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