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Background Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory. Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. Methods Aspidosperma pyrifolium activity was evaluated against...
Malaria remains one of the most serious global infectious diseases. An important target for antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium falciparum (PfDHODH), which is responsible for the conversion of dihydroorotate to orotate in the de novo pyrimidine biosynthetic pathway. In this study, we have designed and synthesized fifteen 7-arylpyrazolo[1,5-a]pyrimidine...
Business Models are formal descriptions representing the components of the business implemented by a company. This provides a strong support in deriving strategic requirements, such as for instance conditions of profitability, that are essential to monitor the operative level. But a strong limitation is that the quantification of the values determining the economical requirements of a model can be...
We present an overview of ODDI an Ontology Driven Data Integration system based on Formal concept analysis and instance comparison. Data Integration systems are used to integrate heterogeneous data sources in a single view. Following the Global-as-View approach the data is retrieved through a common conceptualization, that in our system is modeled as an ontology. This paper focuses on the problem...
The digital business ecosystem is an innovative approach to support the adoption and development of information and communication technologies (ICT). A natural life ecosystem is a biological community of interacting organisms and their physical environments. Conversely, a business ecosystem is a network of buyers, suppliers and makers of related products or services, plus the socio-economic environment...
Organizations are showing growing interest in paradigms where business models and services compatibility is adaptively tested, e.g. by applying automatic systems to check business rules consistency. In this paper, we build on the original proposal by OMG of using first-order logics for representing business vocabularies and propose an approach based on description logics (DL) as formal logic support...
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