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We describe a technology combining nanopore fluidic with surface enhanced Raman spectroscopy (SERS) for real-time, single molecule detection. After optimization of both optical and device design, we can control the nanopore like a valve for molecule motions and detect a single nucleotide even at 10 ms.
Surface Enhanced Raman Scattering (SERS), that occurs by exciting plasmon resonances in metal structures, provides high-sensitivity detection with detailed molecular information. Here we describe the combination of SERS and nanofluidics for the molecular detection inside a plasmonic nanoslit across a thin, metal-coated membrane. The presence of the nanoslit results in mechanical confinement for molecules...
Raman spectroscopy is a widely used vibrational spectroscopic technique to identify and study chemical compounds. The signal can be strongly enhanced in the presence of metal nanostructures resulting in so-called surface-enhanced Raman scattering (SERS). Here, we describe the use of SERS for the molecular characterization of DNA molecules inside a nanoslit across a thin, metal-coated membrane. Nanoslits...
A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single...
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