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Objective
Life stress consistently increases the incidence of major depression. Recent evidence has shown that individual symptoms of major depressive disorder (MDD) differ in important dimensions such as their genetic and etiological background, but the impact of stress on individual MDD symptoms is not known. Here, we assess whether stress affects depression symptoms differentially.
Method
We...
ObjectiveThe high degree of heterogeneity in the development of depression under stress is unaccounted for in traditional statistical modeling. We employ growth mixture modeling to identify classes of individuals at highest risk of depression under stress.
MethodMedical internship was used as a prospective stress model. Interns from US residency programs completed demographic, psychological, and...
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