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We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of pathophysiological modulation of intercellular adhesion. Nanosurgery successfully severs the intermediate filament bundles and disrupts cell–cell adhesion similar to the desmosomal protein disassembly in autoimmune disease, or the cationic modulation of desmosome...
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