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With the advances in biochemistry, molecular biology, and neurochemistry there has been impressive progress in understanding the molecular properties of anesthetic agents. However, there has been little focus on how the molecular properties of anesthetic agents lead to the observed macroscopic property that defines the anesthetic state, that is, lack of responsiveness to noxious stimuli. In this paper,...
With advances in biochemistry, molecular biology, and neurochemistry there has been impressive progress in the understanding of the molecular properties of anesthetic agents. However, despite these advances, we still do not understand how anesthetic agents affect the properties of neurons that translate into the induction of general anesthesia at the macroscopic level. There is extensive experimental...
This paper begins the analysis of optimal control of emergency response logistics under a bioterror attack in the case of anthrax, which is a hybrid system consisting of a continuous-time dynamics and a resetting dynamics. The necessary conditions for time-optimal hybrid control are given, based on the calculus of variations and dynamic programming. A gradient algorithm is implemented and used to...
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