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Poor selectivity and unintended toxicity to normal organs are major challenges in calcium ion (Ca2+) overload tumor therapy. To address this issue, a cell membrane‐anchoring nano‐photosensitizer (CMA‐nPS) is constructed for inducing tumor‐specific Ca2+ overload through multistage endogenous Ca2+ homeostasis disruption under light guidance, i.e., the extracellular Ca2+ influx caused by cell membrane...
Tumor Therapy
In article number 2204689, Xiaoqing Yi, Gengyun Sun, Xiaoyan He, and co‐workers develop a cell membrane‐anchoring nano‐photosensitizer (CMA‐nPS) based on genetically engineered cellular membrane vesicles. The nano‐photosensitizer significantly induces intercellular Ca2+ overload through multistage endogenous homeostasis disruption under laser irradiation. With an obvious synergistic...